منابع مشابه
Feast or famine
Lysosomal storage diseases are metabolic disorders characterized by the accumulation of acidic vacuoles, and are usually the consequence of the deficiency of an enzyme responsible for the metabolism of vesicular lipids, proteins or carbohydrates. In contrast, mucolipidosis type IV (MLIV), results from the absence of a vesicular Ca ( 2+) release channel called mucolipin 1/transient receptor pot...
متن کاملWhither the lipid profile: feast, famine, or no free lunch?
A lipid profile (LP) is used in clinical practice to assess risk of cardiovascular disease (CVD) and to guide therapy. The standard LP includes a direct measurement of plasma total cholesterol, triglyceride, and HDL cholesterol concentrations, and derived estimates of LDL cholesterol, non–HDL cholesterol, and lipid ratios (1 ). Expert guidelines recommend that accurate assessment of the LP requ...
متن کاملLeishmania carbon metabolism in the macrophage phagolysosome- feast or famine?
A number of medically important microbial pathogens target and proliferate within macrophages and other phagocytic cells in their mammalian hosts. While the majority of these pathogens replicate within the host cell cytosol or non-hydrolytic vacuolar compartments, a few, including protists belonging to the genus Leishmania, proliferate long-term within mature lysosome compartments. How these p...
متن کاملCellular sensors of feast and famine.
In response to changes in environmental conditions, animals and humans alike can initiate physiological regulatory mechanisms to assure survival. For example, when food is scarce, the body becomes “thrifty”, and conversely, when it is abundant, physiological “unthrifty” mechanisms are initiated. Recent work has uncovered novel cellular mechanisms of fuel sensing that contribute to these shifts ...
متن کاملFeast or famine? A response to two recent RFC's about network information
In RFC 514, Will Kantrowitz returns to the theme of his superb RFC 459. There are too many people spending too much time asking for too much information about Network Hosts. In RFC 519, John Pickens returns to the theme of his rather querulous RFC 369. It’s not easy to learn how to use network Hosts. On the one hand, it would seem that there’s a veritable feast of information going around; on t...
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ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1218165